在Nature、Science、Nature Methods、Nature Communications、Genome Research（3篇）、Nucleic Acids Research（3篇）、Aging Cell（2篇）、Protein Cell等国际知名杂志发表50余篇SCI研究论文，成果被Nature Methods、Nature Reviews Genetics等评述。申请中美专利15项（7项获授权）。长期致力于mRNA加工成熟的机制及生物学意义研究，聚焦mRNA非编码区（内含子及3′非翻译区）在细胞衰老及衰老相关疾病中的功能机制解析。建立了研究mRNA非编码区的系列方法，揭示了疾病相关点突变及多个重要RNA结合蛋白通过改变mRNA非编码区来调控细胞衰老及衰老相关疾病的分子机制，提出了动态变化的mRNA非编码区调节细胞衰老的新观点，拓展了mRNA非编码区在衰老相关疾病中的生物学意义。主持国家973计划课题和国家重点研发计划课题各一项，主持国家基金委重大研究计划培育项目1项，主持国家基金委面上项目3项，参与国家973计划/重点研发计划课题2项，是基金委创新群体骨干成员。担任中国老年学和老年医学学会老年病学分会衰老基础医学专家委员会副主任委员、上海市遗传学会副秘书长、中国环境诱变剂学会暴露组学与暴露科学专业委员会常务委员等。

代表性论文：

1. Zhao Z#, Xu Q#, Wei R, Huang L, Wang W, Wei G*, Ni T*. Comprehensive characterization of somatic variants associated with intronic polyadenylation in human cancers. Nucleic Acids Res. 2021 Oct 11;49(18):10369-10381.

2. Zhao Z#, Xu Q, Wei R, Wang W, Ding D, Yang Y, Yao J, Zhang L, Hu YQ, Wei G*, Ni T*. Cancer-associated dynamics and potential regulators of intronic polyadenylation revealed by IPAFinder using standard RNA-seq data. Genome Res. 2021 Nov;31(11):2095-2106.

3. Chen M#, Wei R#, Wei G, Xu M, Su Z*, Zhao C*, Ni T*. Systematic evaluation of the effect of polyadenylation signal variants on the expression of disease-associated genes. Genome Res. 2021 May;31(5):890-899.

4. Wang W#, Tan H, Sun M, Han Y, Chen W, Qiu S, Zheng K*, Wei G*, Ni T*. Independent component analysis based gene co-expression network inference (ICAnet) to decipher functional modules for better single-cell clustering and batch integration. Nucleic Acids Res. 2021 May 21;49(9):e54.

5. Yao J#, Ding D#, Li X, Shen T, Fu H, Zhong H, Wei G*, Ni T*. Prevalent intron retention fine-tunes gene expression and contributes to cellular senescence. Aging Cell. 2020 Dec;19(12):e13276.

6. Chen M#, Lyu G#, Han M#, Nie H#, Shen T, Chen W, Niu Y, Song Y, Li X, Li H, Chen X, Wang Z, Xia Z, Li W, Tian XL, Ding C, Gu J, Zheng Y, Liu X, Hu J, Wei G*, Tao W*, Ni T*. 3' UTR lengthening as a novel mechanism in regulating cellular senescence. Genome Res. 2018 Feb 12;28(3):285-294.

7. Shen T#, Li H, Song Y, Yao J, Han M, Yu M, Wei G*, Ni T*. Antisense transcription regulates the expression of sense gene via alternative polyadenylation. Protein Cell. 2018 Jun;9(6):540-552.